This concise and popular introduction to medical microbiology and infection encapsulates the fundamental facts and principles of this rapidly growing and changing subject area. Written by experienced clinicians and teachers, it covers the basic concepts of medical microbiology, and the main human pathogens and infectious syndromes, in an accessible and lucid format. This fully updated fourth edition is now supported by a companion website at www.ataglanceseries.com/medicalmicrobiology containing extra self-assessment cases, colour slides, further reading, and key point summaries. Medical Microbiology and Infection at a Glance is an invaluable revision aid for medical and allied health students and junior doctors, and is ideal for anyone seeking a comprehensive and concise guide to this subject area.
Compatibility of Pharmaceutical Products and Contact Materials Dennis Jenke Important safety aspects of compatibility for therapeutic products and their manufacturing systems, delivery devices, and containers Compatibility of Pharmaceutical Products and Contact Materials helps pharmaceutical, toxicology, analytical, and regulatory affairs professionals assess the safety of leachable and extractable chemicals associated with drug product packaging, manufacturing systems, and devices. The most comprehensive resource available, its coverage includes the strategies, tactics, and regulatory requirements for performing safety assessments, along with the means for interpreting results. Structured around a logical framework for an extractables and leachables safety assessment and closely linked to the pharmaceutical product development process, Compatibility of Pharmaceutical Products and Contact Materials directly addresses the fundamental questions of «what activities need to be performed to completely, efficiently, and effectively address the issue of product safety from an extractables and leachables perspective?» and «when do the various required activities need to be performed?» Specifically, the chapters describe: Pertinent regulations and practical ways to meet guidelines Coordinating manufacturing, storage, and delivery systems development and qualification with therapeutic product development Materials characterization and the materials screening process Component and/or system qualification (illustrated by several case studies) Performing validation/migration studies and interpreting and reporting the results Creating a product registration dossier and putting it through regulatory review Product maintenance (Change Control) from an extractables and leachables perspective Likely future developments in extractables and leachables assessment Additionally, the book's appendix provides a database, including CAS registry numbers, chemical formulas and molecular weights of extractable/leachable substances that have been reported in the chemical literature. Detailing the interconnected roles played by analytical chemistry, biological science, toxicology, and regulatory science, Compatibility of Pharmaceutical Products and Contact Materials supplies a much-needed, comprehensive resource to all those in pharmaceutical product or medical device development.
This book provides useful information for bioanalytical / analytical scientists, analysts, quality assurance managers, and all personnel in bioanalytical laboratories through all aspects of bioanalytical technical and regulatory perspectives within bioanalytical operations and processes. Readers learn how to develop and implement strategies for routine, non-routine, and standard bioanalytical methods and on the entire equipment hardware and software qualification process. The book also gives guidelines on qualification of certified standards and in-house reference material as well as on people qualification. Finally, it guides readers through stressless internal and third party laboratory audits and inspections. It takes account to most national and international regulations and quality and accreditation standards, along with corresponding interpretation and inspection guides. The author elaborates on highly comprehensive content, making it easy not only to learn the subject but also to quickly implement the recommendations.
International Law is the definitive and authoritative text on the subject, offering Shaw's unbeatable combination of clarity of expression and academic rigour and ensuring both understanding and critical analysis in an engaging and authoritative style. Encompassing the leading principles, practice and cases, and retaining and developing the detailed references which encourage and assist the reader in further study, this new edition motivates and challenges students and professionals while remaining accessible and engaging. Fully updated to reflect recent case law and treaty developments, this edition contains an expanded treatment of the relationship between international and domestic law, the principles of international humanitarian law, and international criminal law alongside additional material on international economic law.
An insightful presentation of the key concepts, paradigms, and applications of modeling and simulation Modeling and simulation has become an integral part of research and development across many fields of study, having evolved from a tool to a discipline in less than two decades. Modeling and Simulation Fundamentals offers a comprehensive and authoritative treatment of the topic and includes definitions, paradigms, and applications to equip readers with the skills needed to work successfully as developers and users of modeling and simulation. Featuring contributions written by leading experts in the field, the book's fluid presentation builds from topic to topic and provides the foundation and theoretical underpinnings of modeling and simulation. First, an introduction to the topic is presented, including related terminology, examples of model development, and various domains of modeling and simulation. Subsequent chapters develop the necessary mathematical background needed to understand modeling and simulation topics, model types, and the importance of visualization. In addition, Monte Carlo simulation, continuous simulation, and discrete event simulation are thoroughly discussed, all of which are significant to a complete understanding of modeling and simulation. The book also features chapters that outline sophisticated methodologies, verification and validation, and the importance of interoperability. A related FTP site features color representations of the book's numerous figures. Modeling and Simulation Fundamentals encompasses a comprehensive study of the discipline and is an excellent book for modeling and simulation courses at the upper-undergraduate and graduate levels. It is also a valuable reference for researchers and practitioners in the fields of computational statistics, engineering, and computer science who use statistical modeling techniques.
Sets forth what to do and what not to do to keep people and property safe Based on the author's more than two decades of managing core facets of emergency planning and response, this book enables readers to minimize the possibility of a chemical, biological, radiological, or nuclear (CBRN) disaster or a hazardous material (hazmat) incident at public events. Moreover, it sets forth the tools needed to quickly respond to an incident in order to avoid or minimize casualties and damages. With its comprehensive approach, the book equips readers to plan for and manage a multi-disciplinary safety and emergency response team, including police, security, medical, military, and fire and civil protection personnel. CBRN and Hazmat Incidents at Major Public Events examines all aspects of security planning and emergency response, including: General planning and preparedness procedures such as initial considerations, response network development, and training and exercise Planning and preparedness for security and emergency response providers, including medical, fire, police, military, and VIP protection personnel Incident response, including initial response, detection and identification, and law enforcement Lastly, the author provides fourteen specific public event scenarios, explaining what to do and what not to do for effective emergency planning and response to CBRN and hazmat incidents. These scenarios also set the foundation for preparedness training and exercises. Throughout the book, sidebars summarize the author's extensive operational and managerial experience, helping readers focus on the core tested and proven strategies and techniques needed to prevent or mitigate the impact of a CBRN or hazmat incident. With its unique focus on CBRN and hazmats, this book is essential reading for all personnel charged with protecting lives and property at large public events.
The second edition of Anaesthetic and Sedative Techniques for Aquatic Animals provided the fisheries and aquaculture industry with vital information on the use of sedation and anaesthetics in the avoidance of stress and physical damage, which can easily be caused by crowding, capture, handling, transportation and release. Now fully revised and expanded, the third edition has maintained its accessible format and incorporates much new emphasis on: • Fish pain and welfare: a rapidly developing area of interest and debate • Anaesthesia and legislation: with an international perspective Personnel involved in the aquaculture industry including fish farmers, fish veterinarians, fisheries scientists and fish biologists along with small animal veterinarians, animal laboratory managers and government and regulatory personnel will find this book a valuable and practical resource.
Management of Pregnant and Neonatal Dogs, Cats, and Exotic Pets is a comprehensive yet practical reference on small animal neonatology. Covering reproductive physiology of pregnancy and parturition, normal neonatology, and neonatal disorders in dogs, cats, and small exotic mammals, the book gives special emphasis to fetal well-being, parturition, normal physical parameters, behavior, common disorders and defects, emergency care, and orphan management. Information on nutritional and environmental considerations for both the dam and offspring is included, as well as guidance on offering advice to breeders providing neonatal care at home. Well illustrated throughout, Management of Pregnant and Neonatal Dogs, Cats, and Exotic Pets is a complete resource for the successful management of pregnant and newborn pets. Veterinary practitioners, students, technicians, and professional breeders all will find the book’s how-to, clinically relevant approach to small animal neonatology invaluable.
The essential guide to investing in mining opportunities, now in its Fourth Edition A comprehensive guide to mining investment analysis designed for use by financial and mining analysts, executives, and investors, The Mining Valuation Handbook: Mining and Energy Valuation for Investors and Management has become an essential resource for assessing the value and investment potential of mining opportunities. Fully revised and updated, this fourth edition of the classic text provides new and up-to-date information to better explain the mysteries surrounding the resources industry. Written by Victor Rudenno, a leading global expert on mining investment analysis and consultant to mining companies, financial bodies, and governments, The Mining Valuation Handbook: Mining and Energy Valuation for Investors and Management, Fourth Edition covers a wide range of essential topics, including: feasibility studies, commodity values and forecasting, classification of resources and reserves, indicative capital and operating costs, valuation and pricing techniques, qualifying risk, the impact of exploration and expansion, and more. Fourth edition of the bestselling text on assessing mining investment opportunities Author Victor Rudenno is a respected global expert on mining investment analysis Key topics, including feasibility studies, valuation techniques, and risk qualification are covered in detail Packed with invaluable mining information for the financial industry and financial information for the mining industry, The Mining Valuation Handbook is the definitive guide to assessing and investing in mining opportunities.
This new and completely revised third edition is a concise, systematic and highly practical guide to the care of patients with Type 1 and Type 2 diabetes. Clinically and problem-based, it covers emergency, inpatient and ambulatory diabetes care in the hospital and community, focusing particularly on difficult, grey and contentious areas of management, and seeks to guide advanced practitioners through problems that are not always emphasised. Up to date clinical trial results have been incorporated, as well as concise discussions of lifestyle approaches to diabetes management, and it includes a new chapter on psychological problems in diabetes. It is now fully referenced with PubMed PMID numbers and all HbA1c measurements are quoted in DCCT and IFCC units. It will be valuable for foundation year and specialist trainees in general medicine, diabetes and endocrinology; community and hospital diabetes specialist nurses and nurse practitioners; hospital-based ward staff in specialist and non-diabetes-specialist departments, especially cardiology and emergency medicine; and general practice diabetes leads and general practitioners with a specialist diabetes interest. It will be equally valuable for hands-on reference use in the clinical situation, and for clinicians in hospital medicine and general practice studying for postgraduate diplomas and examinations.
Food and Industrial Bioproducts and Bioprocessing describes the engineering aspects of bioprocessing, including advanced food processing techniques and bioproduct development. The main focus of the book is on food applications, while numerous industrial applications are highlighted as well. The editors and authors, all experts in various bioprocessing fields, cover the latest developments in the industry and provide perspective on new and potential products and processes. Challenges and opportunities facing the bioproduct manufacturing industry are also discussed. Coverage is far-reaching and includes: current and future biomass sources and bioprocesses; oilseed processing and refining; starch and protein processing; non-thermal food processing; fermentation; extraction techniques; enzymatic conversions; nanotechnology; microencapsulation and emulsion techniques; bioproducts from fungi and algae; biopolymers; and biodegradable/edible packaging. Researchers and product developers in food science, agriculture, engineering, bioprocessing and bioproduct development will find Food and Industrial Bioproducts and Bioprocessing an invaluable resource.
A comprehensive guide to computer assisted exercises Readers can turn to this indispensable reference guide for comprehensive and lucid coverage of the operational, technical, and organizational knowledge needed to harness successful and constructive computer assisted exercises (CAX) and war games. It is geared also toward large civilian organizations that are looking to teach and test their strategies and procedures without the added cost of manpower. Divided into two clear parts, the book covers: Fundamentals and Theory—conflict and warfare; probability and statistics; simulation; distributed simulation; and experimentation and analysis Combat Modeling, Computer Assisted Exercises, and Practice—CAX architectures; CAX process; combat modeling; CAX support tools; communications/information system issues, technical risks, and risk miti-gation; and exercise centers and facilities Computer Assisted Exercises and Training: A Reference Guide is indispensable reading for research engineers, computer scientists, software engineers working with modeling and simulation, homeland security specialists, staff in simulation training centers, military strategists and commanders, and many others. It also serves as a valuable textbook for modeling and simulation courses at the upper-undergraduate and graduate levels.
Provides options for implementing IPv6 and IPv6 multicast in service provider networks New technologies, viewing paradigms, and content distribution approaches are taking the TV/video services industry by storm. Linear and Nonlinear Video and TV Applications: Using IPv6 and IPv6 Multicast identifies five emerging trends in next-generation delivery of entertainment-quality video. These trends are observable and can be capitalized upon by progressive service providers, telcos, cable operators, and ISPs. This comprehensive guide explores these evolving directions in the TV/video services industry, including worldwide deployment of IPv6, IPTV services, web-produced video content, and the plethora of different screens available, from TV to iPad. It offers practical suggestions as to how these technologies can be implemented in service provider networks to support cost-effective delivery of entertainment, and how new revenue-generating services can be brought to market. Important topics include: Evolving video consumption habits and possible network implications An overview of IPv6 address capabilities, protocols, quality of service (QoS), and more Process descriptions of IP multicast and IPv6 multicast approaches and challenges A detailed overview of IPTV systems and technologies, including architectural requirements, QoE and QoS, security and content protection, networks, and more Internet-based TV technologies: streaming, content distribution networks, P2P networks, and cloud computing Non-traditional video content sources and their implications Linear and Nonlinear Video and TV Applications: Using IPv6 and IPv6 Multicast is indispensable reading for planners, CTOs, and engineers at broadcast TV operations, Cable TV operations, satellite operations, Internet and IS providers, telcos, and wireless providers.
This book provides up to date coverage of the basics of ATM and internet protocols, and characteristics of satellite networks and internetworking between satellite and terrestrial networks Satellite Networking: Principles and Protocols, Second Edition provides up to date information of the original topics in satellite networking and protocols focusing on Internet Protocols (IP) over satellites, broadband over satellites, next generation IP (IPv6) over satellites, new generation of DVB-S/S2 and DVB-RCS next generations and new services and applications. It also includes some analytical techniques for evaluation of end to end IP performance and QoS over satellite, reflecting the recent convergence of telecommunication, Internet, broadcasting and mobile networks. Topics new to this edition: Internetworking with MANET, DVB-S/S2 and DVB-RCS/RCS2 (including TCP/IP over DVB-S/RCS), recent developments in broadband satellite systems, convergence of services and network technologies (including Internet, telecom, mobile, TV, etc.), radio resource management, PEP, I-PEP, SCPS, traffic modelling and engineering with analysis and examples, and future developments of satellite networking. Provides up to date coverage of the basics of ATM and internet protocols, and characteristics of satellite networks and internetworking between satellite and terrestrial networks (e.g. mobile ad hoc networks), including coverage of new services and applications (e.g. Internet, telecom, mobile and TV) Discusses the real-time protocols including RTP, RTCP and SIP for real-time applications such as VoIP and MMC, and explains TCP/IP over satellite and evolution of IPv6 over satellite and beyond
The Sparidae, commonly known as breams and porgies, is a family of fishes of the order Perciformes, and includes about 115 species of mainly marine coastal fish of high economic value, exploited and farmed for human consumption, as well as for recreational purposes. This landmark publication brings together a huge wealth of information on the biology and culture of gilthead sea bream and other Sparidae species. Commencing with an overview of the current status of aquaculture of Sparidae, the book continues with comprehensive coverage of the family’s phylogeny, evolution and taxonomy, stress and welfare issues, and reproduction and broodstock management. Further chapters include coverage of early development and metabolism, production systems, nutrition, quality, and health management. A final cutting-edge chapter looks at genomic-proteomic research in Sparidae and its application to genetic improvement. With contributions from Europe, the Middle East, Asia, Australasia and North America, carefully drawn together and edited by Professor M. Pavlidis and Dr C. C. Mylonas, themselves well known for their work in this area, Sparidae is an essential purchase for anyone working with this important family of fishes. Fish biologists, fish farmers, aquaculture researchers, and fisheries managers will all find much of great use and interest within this book’s covers. All universities and research establishments where biological sciences, aquaculture and fisheries science are studied and taught should have copies of this excellent book on their shelves.
This wide ranging and challenging book explores the relationship between subjectivity and mortality as it is understood by a number of twentieth-century French philosophers including Sartre, Lacan, Levinas and Derrida. Making intricate and sometimes unexpected connections, Christina Howells draws together the work of prominent thinkers from the fields of phenomenology and existentialism, religious thought, psychoanalysis, and deconstruction, focussing in particular on the relations between body and soul, love and death, desire and passion. From Aristotle through to contemporary analytic philosophy and neuroscience the relationship between mind and body (psyche and soma, consciousness and brain) has been persistently recalcitrant to analysis, and emotion (or passion) is the locus where the explanatory gap is most keenly identified. This problematic forms the broad backdrop to the work’s primary focus on contemporary French philosophy and its attempts to understand the intimate relationship between subjectivity and mortality, in the light not only of the ‘death’ of the classical subject but also of the very real frailty of the subject as it lives on, finite, desiring, embodied, open to alterity and always incomplete. Ultimately Howells identifies this vulnerability and finitude as the paradoxical strength of the mortal subject and as what permits its transcendence. Subtle, beautifully written, and cogently argued, this book will be invaluable for students and scholars interested in contemporary theories of subjectivity, as well as for readers intrigued by the perennial connections between love and death.