Compatibility of Pharmaceutical Products and Contact Materials Dennis Jenke Important safety aspects of compatibility for therapeutic products and their manufacturing systems, delivery devices, and containers Compatibility of Pharmaceutical Products and Contact Materials helps pharmaceutical, toxicology, analytical, and regulatory affairs professionals assess the safety of leachable and extractable chemicals associated with drug product packaging, manufacturing systems, and devices. The most comprehensive resource available, its coverage includes the strategies, tactics, and regulatory requirements for performing safety assessments, along with the means for interpreting results. Structured around a logical framework for an extractables and leachables safety assessment and closely linked to the pharmaceutical product development process, Compatibility of Pharmaceutical Products and Contact Materials directly addresses the fundamental questions of «what activities need to be performed to completely, efficiently, and effectively address the issue of product safety from an extractables and leachables perspective?» and «when do the various required activities need to be performed?» Specifically, the chapters describe: Pertinent regulations and practical ways to meet guidelines Coordinating manufacturing, storage, and delivery systems development and qualification with therapeutic product development Materials characterization and the materials screening process Component and/or system qualification (illustrated by several case studies) Performing validation/migration studies and interpreting and reporting the results Creating a product registration dossier and putting it through regulatory review Product maintenance (Change Control) from an extractables and leachables perspective Likely future developments in extractables and leachables assessment Additionally, the book's appendix provides a database, including CAS registry numbers, chemical formulas and molecular weights of extractable/leachable substances that have been reported in the chemical literature. Detailing the interconnected roles played by analytical chemistry, biological science, toxicology, and regulatory science, Compatibility of Pharmaceutical Products and Contact Materials supplies a much-needed, comprehensive resource to all those in pharmaceutical product or medical device development.
Up-to-date, reliable information about Tourette Syndrome and related disorders for teachers and parents Children with TS are often teased and punished for the unusual yet uncontrollable symptoms of their disorder. Academic failure is common. The Tourette Syndrome/OCD Checklist helps parents and teachers to better understand children and youth with TS and/or OCD and provide the support and interventions these children need. Presented in a simple, concise, easy-to-read checklist format, the book is packed with the latest research, practical advice, and information on a wide range of topics. Provides a wealth of information on Tourette Syndrome, Obsessive-Compulsive Disorder, and related conditions Includes strategies for discipline and behavior management, advice on supporting and motivating kids with TS and OCD, homework tips, and more Shows how to educate peer students about TS and OCD Loaded with practical information, strategies, and resources, this book helps parents and teachers to better understand Tourette Syndrome and OCD and shows how every individual can reach their potential in school and in life.
Your one-stop Photoshop reference, filled with the latest tips and techniques There’s a reason why Photoshop is the industry standard for image-editing software. But it’s also that big, Photoshop has so many facets and features that a handy one-stop guide is exactly what you need. And you’ll love the “Putting It Together” exercises that give you hands-on experience – in rich, full color! Learn the parts – the desktop, menus, panels, and key tools, and how to use Adobe Bridge Make your selection – learn about each of the selection tools plus the powerful Pen tool and Paths panel Brush up – on the Brush and Pencil tools and how to create vector shapes, create and edit type, and put type on a path Restore and retouch – correct and enhance color, improve contrast, and use the Clone Stamp and Healing tools to fix flaws and damage Print it – learn how to get the right resolution, image mode, and file format, and prepare your work for printing Open the book and find: How to crop images and increase their canvas size Tips for creating gradients and patterns Advice on resizing images How to composite images with layers and blending modes Filter techniques to correct or alter images How the Vanishing Point feature makes editing easier Steps for making adjustments with levels and curves How to create contact sheets
Women and Poverty analyzes the social and structural factors that contribute to, and legitimize, class inequity and women's poverty. In doing so, the book provides a unique documentation of women's experiences of poverty and classism at the individual and interpersonal levels. Provides readers with a critical analysis of the social and structural factors that contribute to women's poverty Uses a multidisciplinary approach to bring together new research and theory from social psychology, policy studies, and critical and feminist scholarship Documents women's experiences of poverty and classism at the interpersonal and institutional levels Discusses policy analysis for reducing poverty and social inequality
Food and Industrial Bioproducts and Bioprocessing describes the engineering aspects of bioprocessing, including advanced food processing techniques and bioproduct development. The main focus of the book is on food applications, while numerous industrial applications are highlighted as well. The editors and authors, all experts in various bioprocessing fields, cover the latest developments in the industry and provide perspective on new and potential products and processes. Challenges and opportunities facing the bioproduct manufacturing industry are also discussed. Coverage is far-reaching and includes: current and future biomass sources and bioprocesses; oilseed processing and refining; starch and protein processing; non-thermal food processing; fermentation; extraction techniques; enzymatic conversions; nanotechnology; microencapsulation and emulsion techniques; bioproducts from fungi and algae; biopolymers; and biodegradable/edible packaging. Researchers and product developers in food science, agriculture, engineering, bioprocessing and bioproduct development will find Food and Industrial Bioproducts and Bioprocessing an invaluable resource.
The essential guide to investing in mining opportunities, now in its Fourth Edition A comprehensive guide to mining investment analysis designed for use by financial and mining analysts, executives, and investors, The Mining Valuation Handbook: Mining and Energy Valuation for Investors and Management has become an essential resource for assessing the value and investment potential of mining opportunities. Fully revised and updated, this fourth edition of the classic text provides new and up-to-date information to better explain the mysteries surrounding the resources industry. Written by Victor Rudenno, a leading global expert on mining investment analysis and consultant to mining companies, financial bodies, and governments, The Mining Valuation Handbook: Mining and Energy Valuation for Investors and Management, Fourth Edition covers a wide range of essential topics, including: feasibility studies, commodity values and forecasting, classification of resources and reserves, indicative capital and operating costs, valuation and pricing techniques, qualifying risk, the impact of exploration and expansion, and more. Fourth edition of the bestselling text on assessing mining investment opportunities Author Victor Rudenno is a respected global expert on mining investment analysis Key topics, including feasibility studies, valuation techniques, and risk qualification are covered in detail Packed with invaluable mining information for the financial industry and financial information for the mining industry, The Mining Valuation Handbook is the definitive guide to assessing and investing in mining opportunities.
This wide ranging and challenging book explores the relationship between subjectivity and mortality as it is understood by a number of twentieth-century French philosophers including Sartre, Lacan, Levinas and Derrida. Making intricate and sometimes unexpected connections, Christina Howells draws together the work of prominent thinkers from the fields of phenomenology and existentialism, religious thought, psychoanalysis, and deconstruction, focussing in particular on the relations between body and soul, love and death, desire and passion. From Aristotle through to contemporary analytic philosophy and neuroscience the relationship between mind and body (psyche and soma, consciousness and brain) has been persistently recalcitrant to analysis, and emotion (or passion) is the locus where the explanatory gap is most keenly identified. This problematic forms the broad backdrop to the work’s primary focus on contemporary French philosophy and its attempts to understand the intimate relationship between subjectivity and mortality, in the light not only of the ‘death’ of the classical subject but also of the very real frailty of the subject as it lives on, finite, desiring, embodied, open to alterity and always incomplete. Ultimately Howells identifies this vulnerability and finitude as the paradoxical strength of the mortal subject and as what permits its transcendence. Subtle, beautifully written, and cogently argued, this book will be invaluable for students and scholars interested in contemporary theories of subjectivity, as well as for readers intrigued by the perennial connections between love and death.
A thorough treatment of product and systems development in terms of value to all stakeholders Product and Systems Development compiles more than twenty years of research and practice from a value perspective, from vision and marketing to design, manufacturing, delivery, operations, and maintenance. It defines stakeholder value and identifies specific stakeholders in the product and system development process; covers best practices in development; and examines systems engineering, current industry views, and the life cycle of a value stream. Featuring appendices written by professionals in the field on topics such as Design Structure Matrices, Lean Enablers for systems engineering, and MDAO and simulations, this indispensable guide: Explains why stakeholders' values can hold the key to fulfillment or defeat of the developer's vision Emphasizes the succession of value-contributing practices and tools that form a framework for development success Integrates the technical, productivity, and customer/end-user elements in product and system development Uses more than 100 tables and figures to illustrate the above processes, as well as corollary elements of risk, failure analysis, and fault-tolerant design Includes numerous case studies and links to online material Product and Systems Development is an excellent coursebook for senior and graduate students in aerospace, mechanical, civil, electrical, and material engineering, as well as management science and engineering. It is also a useful reference for practicing engineers in a variety of technology-based industries.
The latest edition of one of the bestselling Microsoft Office books of all time! Spend less time figuring out Word, Excel, PowerPoint, Outlook, and Access and more time working on actual projects with this new edition of Office 2010 For Dummies. Filled with straightforward, friendly instruction, this book gets you thoroughly up to speed, and it actually makes doing Office work fun! First learn all the basics, then how to add more bells and whistles, including how to spice up your Word documents, edit Excel spreadsheets and create formulas, add sound to your PowerPoint presentation, and much more. Helps you harness the power of Microsoft Office 2010 and all of its new functionality; the book covers Word, Excel, PowerPoint, Outlook, and Access Explains and instructs in the straightforward, friendly, For Dummies style that makes instruction more accessible and skill-building easier Covers typing and formatting text in Word and spicing up your documents Shows you how to navigate and edit an Excel spreadsheet, create formulas, and chart and analyze Excel data Demonstrates how to create a PowerPoint presentation and add color, sound, and pictures Explores Outlook, including configuring e-mail, storing contacts, organizing tasks, scheduling your time, and setting appointments Delves into designing Access databases, including editing, modifying, searching, sorting, and querying; also covers viewing and printing reports, and more Be ready to take full advantage of Microsoft Office 2010 with this fun and easy guide.
Sets forth what to do and what not to do to keep people and property safe Based on the author's more than two decades of managing core facets of emergency planning and response, this book enables readers to minimize the possibility of a chemical, biological, radiological, or nuclear (CBRN) disaster or a hazardous material (hazmat) incident at public events. Moreover, it sets forth the tools needed to quickly respond to an incident in order to avoid or minimize casualties and damages. With its comprehensive approach, the book equips readers to plan for and manage a multi-disciplinary safety and emergency response team, including police, security, medical, military, and fire and civil protection personnel. CBRN and Hazmat Incidents at Major Public Events examines all aspects of security planning and emergency response, including: General planning and preparedness procedures such as initial considerations, response network development, and training and exercise Planning and preparedness for security and emergency response providers, including medical, fire, police, military, and VIP protection personnel Incident response, including initial response, detection and identification, and law enforcement Lastly, the author provides fourteen specific public event scenarios, explaining what to do and what not to do for effective emergency planning and response to CBRN and hazmat incidents. These scenarios also set the foundation for preparedness training and exercises. Throughout the book, sidebars summarize the author's extensive operational and managerial experience, helping readers focus on the core tested and proven strategies and techniques needed to prevent or mitigate the impact of a CBRN or hazmat incident. With its unique focus on CBRN and hazmats, this book is essential reading for all personnel charged with protecting lives and property at large public events.
Introducing the tools of statistics and probability from the ground up An understanding of statistical tools is essential for engineers and scientists who often need to deal with data analysis over the course of their work. Statistics and Probability with Applications for Engineers and Scientists walks readers through a wide range of popular statistical techniques, explaining step-by-step how to generate, analyze, and interpret data for diverse applications in engineering and the natural sciences. Unique among books of this kind, Statistics and Probability with Applications for Engineers and Scientists covers descriptive statistics first, then goes on to discuss the fundamentals of probability theory. Along with case studies, examples, and real-world data sets, the book incorporates clear instructions on how to use the statistical packages Minitab® and Microsoft® Office Excel® to analyze various data sets. The book also features: • Detailed discussions on sampling distributions, statistical estimation of population parameters, hypothesis testing, reliability theory, statistical quality control including Phase I and Phase II control charts, and process capability indices • A clear presentation of nonparametric methods and simple and multiple linear regression methods, as well as a brief discussion on logistic regression method • Comprehensive guidance on the design of experiments, including randomized block designs, one- and two-way layout designs, Latin square designs, random effects and mixed effects models, factorial and fractional factorial designs, and response surface methodology • A companion website containing data sets for Minitab and Microsoft Office Excel, as well as JMP ® routines and results Assuming no background in probability and statistics, Statistics and Probability with Applications for Engineers and Scientists features a unique, yet tried-and-true, approach that is ideal for all undergraduate students as well as statistical practitioners who analyze and illustrate real-world data in engineering and the natural sciences.
RF and Microwave Transmitter Design is unique in its coverage of both historical transmitter design and cutting edge technologies. This text explores the results of well-known and new theoretical analyses, while informing readers of modern radio transmitters' pracitcal designs and their components. Jam-packed with information, this book broadcasts and streamlines the author's considerable experience in RF and microwave design and development.
Sustainable Geography recalls the system and laws of geographical space production, tackles the hardcore of geography and presents models and organizations through a regional analysis and the dynamics of territorial structures and methods. The book also describes the general idea of discontinuities, trenches, the anti-dialectical and redivision-uniformity in the globalization and addresses the Transnational Urban Systems and Urban Network in Europe.
This new and completely revised third edition is a concise, systematic and highly practical guide to the care of patients with Type 1 and Type 2 diabetes. Clinically and problem-based, it covers emergency, inpatient and ambulatory diabetes care in the hospital and community, focusing particularly on difficult, grey and contentious areas of management, and seeks to guide advanced practitioners through problems that are not always emphasised. Up to date clinical trial results have been incorporated, as well as concise discussions of lifestyle approaches to diabetes management, and it includes a new chapter on psychological problems in diabetes. It is now fully referenced with PubMed PMID numbers and all HbA1c measurements are quoted in DCCT and IFCC units. It will be valuable for foundation year and specialist trainees in general medicine, diabetes and endocrinology; community and hospital diabetes specialist nurses and nurse practitioners; hospital-based ward staff in specialist and non-diabetes-specialist departments, especially cardiology and emergency medicine; and general practice diabetes leads and general practitioners with a specialist diabetes interest. It will be equally valuable for hands-on reference use in the clinical situation, and for clinicians in hospital medicine and general practice studying for postgraduate diplomas and examinations.
The Sparidae, commonly known as breams and porgies, is a family of fishes of the order Perciformes, and includes about 115 species of mainly marine coastal fish of high economic value, exploited and farmed for human consumption, as well as for recreational purposes. This landmark publication brings together a huge wealth of information on the biology and culture of gilthead sea bream and other Sparidae species. Commencing with an overview of the current status of aquaculture of Sparidae, the book continues with comprehensive coverage of the family’s phylogeny, evolution and taxonomy, stress and welfare issues, and reproduction and broodstock management. Further chapters include coverage of early development and metabolism, production systems, nutrition, quality, and health management. A final cutting-edge chapter looks at genomic-proteomic research in Sparidae and its application to genetic improvement. With contributions from Europe, the Middle East, Asia, Australasia and North America, carefully drawn together and edited by Professor M. Pavlidis and Dr C. C. Mylonas, themselves well known for their work in this area, Sparidae is an essential purchase for anyone working with this important family of fishes. Fish biologists, fish farmers, aquaculture researchers, and fisheries managers will all find much of great use and interest within this book’s covers. All universities and research establishments where biological sciences, aquaculture and fisheries science are studied and taught should have copies of this excellent book on their shelves.
Uncover hidden patterns of data and respond with countermeasures Security professionals need all the tools at their disposal to increase their visibility in order to prevent security breaches and attacks. This careful guide explores two of the most powerful ? data analysis and visualization. You'll soon understand how to harness and wield data, from collection and storage to management and analysis as well as visualization and presentation. Using a hands-on approach with real-world examples, this book shows you how to gather feedback, measure the effectiveness of your security methods, and make better decisions. Everything in this book will have practical application for information security professionals. Helps IT and security professionals understand and use data, so they can thwart attacks and understand and visualize vulnerabilities in their networks Includes more than a dozen real-world examples and hands-on exercises that demonstrate how to analyze security data and intelligence and translate that information into visualizations that make plain how to prevent attacks Covers topics such as how to acquire and prepare security data, use simple statistical methods to detect malware, predict rogue behavior, correlate security events, and more Written by a team of well-known experts in the field of security and data analysis Lock down your networks, prevent hacks, and thwart malware by improving visibility into the environment, all through the power of data and Security Using Data Analysis, Visualization, and Dashboards.