Using examples and case studies from industry, academia and research literature, Randomized Clinical Trials provides a detailed overview of the key issues involved in designing, conducting, analysing and reporting randomized clinical trials. It examines the methodology for conducting Phase III clinical trials, developing the protocols, the practice for capturing, measuring, and analysing the resulting clinical data and their subsequent reporting. Randomized clinical trials are the principal method for determining the relative efficacy and safety of alternative treatments, interventions or medical devices. They are conducted by groups comprising one or more of pharmaceutical and allied health-care organisations, academic institutions, and charity supported research groups. In many cases such trials provide the key evidence necessary for the regulatory approval of a new product for future patient use. Randomized Clinical Trials provides comprehensive coverage of such trials, ranging from elementary to advanced level. Written by authors with considerable experience of clinical trials, Randomized Clinical Trials is an authoritative guide for clinicians, nurses, data managers and medical statisticians involved in clinical trials research and for health care professionals directly involved in patient care in a clinical trial context.
A user-friendly guide of best practice for leading groups in various settings and with different populations, which incorporates the latest developments in today's mental health marketplace. Features multiple theoretical perspectives and guidelines for running groups for diverse populations, in the US and worldwide Offers modern approaches and practical suggestions in a user-friendly and jargon-free style, with many clinical examples Includes a major component on resiliency and trauma relief work, and explores its impact on clinicians Accompanied by an online resource featuring discussions of psychotherapeutic techniques in practice
Development of Vaccines: From Discovery to Clinical Testing outlines the critical steps, and analytical tools and techniques, needed to take a vaccine from discovery through a successful clinical trial. Contributions from leading experts in the critical areas of vaccine expression, purification, formulation, pre-clinical testing and regulatory submissions make this book an authoritative collection of issues, challenges and solutions for progressing a biologic drug formulation from its early stage of discovery into its final clinical testing. A section with details and real-life experiences of toxicology testing and regulatory filing for vaccines is also included.
A comprehensive guide to the identification, assessment, and treatment of child sexual abuse The field of child sexual abuse has experienced an explosion of research, literature, and enhanced treatment methods over the last thirty years. Representing the latest refinements of thought in this field, Handbook of Child Sexual Abuse: Identification, Assessment, and Treatment combines the most current research with a wealth of clinical experience. The contributing authors, many of whom are pioneers in their respective specialties, include researchers and clinicians, forensic interviewers and law enforcement professionals, caseworkers and victim advocates, all of whom do the work of helping children who have been sexually victimized. Offering a snapshot of the state of the field as it stands today, Handbook of Child Sexual Abuse explores a variety of issues related to child sexual abuse, from identification, assessment, and treatment methods to models for implementation and prevention, including: The impact of sexual abuse on the developing brain The potential implications of early sexual victimization Navigating the complexities of multidisciplinary teams Forensic interviewing and clinical assessment Treatment options for children who have traumagenic symptoms as a response to their sexual victimization Treating children with sexual behavior problems and adolescents who engage in illegal sexual behavior Secondary trauma and vicarious traumatization Cultural considerations and prevention efforts Edited by a leader in the field of child therapy, this important reference equips helping professionals on the front lines in the battle against child sexual abuse—not merely with state-of-the-art knowledge—but also with a renewed vision for the importance of their role in the shaping of our culture and the healing of victimized children.
This book will be an affordable, highly practical handbook on hepatology, aimed at residents/trainees in gastroenterology, GI nurses, and recently qualified consultants to use as a quick reference when managing patients presenting with possible or overt liver disease. It will be of particular use for those GI internists/residents who have an interest specifically in hepatology. It does not aim to be a specialist textbook, but a shorter, 250pp guide that provides key clinical information on each area of hepatology in an accessible form. Extracting relevant material from large reference textbooks can be very time consuming and for this reason, information in this handbook will be presented succinctly in a style suitable for quick reference and easy understanding. The chief emphasis will be on the clinical assessment and management of these patients, and all the major areas of liver disease will be covered, from liver cirrhosis to viral hepatitis, to autoimmune liver failure. Chapters will use a variety of structural features and colour coded boxes to increase the accessibility for residents. These include: key points/take-home points, case history, practice points and management algorithm/flow-charts. Each chapter will also contain sample multiple choice questions that the reader will be able to test themselves on.
Case formulation is a key skill for mental health practitioners, and this book provides examples of ten case formulations representing the most common mental health problems in a variety of populations and contexts, offering commentary on contrasting formulations of the same case. Provides an overview of the general features of case formulation and how it can drive treatment Features clinical cases from a variety of populations, focusing on a range of different problems Covers all the major theoretical perspectives in clinical practice – behavioural, cognitive behavioural, psychodynamic, medical , and eclectic Offers commentary on contrasting formulations of the same case for five different clinical problems
Rheumatology Practice in Occupational Therapy: Promoting Lifestyle Management is a valuable new handbook focusing on rheumatology, a core area of occupational therapy practice. It provides practical guidance to help occupational therapists treat and manage rheumatic conditions in both clinical and community settings and emphasises a contemporary ‘client-centred’ approach as a fundamental requirement of effective and rewarding occupational therapy practice. Drawing upon personal, clinical and theoretical perspectives, Rheumatology Practice in Occupational Therapy equips the reader with an understanding of the relevant practical skills and of the clinical reasoning required to modify and apply these skills to the needs of individual people. Written by experts from occupational therapy, sociology and psychology, this book addresses the need to adapt occupational therapy interventions to each client’s own experience of living with a rheumatic condition and develops the reader’s understanding of key theoretical and clinical approaches to person-centred management. Rheumatology Practice in Occupational Therapy is essential reading for all occupational therapists helping people with rheumatic conditions in hospital and community settings, and for students preparing for practice. It will also be of interest to other healthcare professionals working with people with these conditions. • Includes personal narratives of people trying to live their lives within the context of a debilitating condition • Promotes understanding of key theoretical and clinical approaches to person-centred management • Written by authors with extensive experience in clinical and research contexts • Offers practical resource sections at the end of each chapter Related titles Occupational Therapy and Older People, 2nd Edition Anita Atwal, Anne McIntyre 978-1-4443-3333-6 Role Emerging Occupational Therapy: Maximising Occupation Focused Practice Miranda Thew, Mary Edwards, Sue Baptiste, Matthew Molineux 978-1-4051-9782-3 Interprofessional Rehabilitation: A Person-Centred Approach Sarah G. Dean, Richard J. Siegert, William J. Taylor 978-0-470-65596-2
Integrated Clinical Orthodontics provides an important new resource on the clinical interactions between the practice of orthodontics and other areas of clinical dentistry and medicine. Having at its heart the paradigm of patient-centred care, the book not only integrates the knowledge, skills, and experience of all the disciplines of dentistry and medicine, but also eases the work of orthodontists in arriving at an accurate diagnosis and a comprehensive treatment plan. Presented in a highly visual and practical format, Integrated Clinical Orthodontics uses clinical case presentations to illustrate the rationale and application of the integrated approach to a variety of clinical scenarios. Integrated Clinical Orthodontics covers areas of complexity in clinical orthodontics, specifically the role of the orthodontist as a member of a multidisciplinary team. The book outlines and details the management of congenital orofacial deformities, sleep disorders, esthetic smile creation and temporomandibular joint problems, and additionally and importantly includes specific protocols for effective communication with experts in other specialties.
Wiley-Blackwell Handbook of the Treatment of Childhood and Adolescent Anxiety presents a collection of readings from leading experts that reveal the most effective evidence-based interventions for the prevention and treatment of anxiety disorders in children and adolescents. Features expertise of the foremost scientist-practitioners in the field of child and adolescent anxiety Includes state-of-the art information on psychological interventions from each author Written in a clear and easy-to-follow manner for a wide audience
Wiley's new Handbook of Decision Making is a vital reference text for all students and professionals of management, organization and decision making. The handbook offers a wide range of theoretical and empirical approaches to the understanding of organizational and strategic decisions. Contributors are internationally known experts drawn from North America, Canada and Europe who have spent many years in the study of decision making, and decision making relevant topics. We believe the handbook will become a tour de force in the understanding decision making, offering a wide variety of perspectives, topics, and summative understanding of the field. Chapters in the Handbook were prepared by the leading experts in their field and include cutting edge empirical, theoretical, and review chapters. The chapters bring together for the first time a critical mass of writing on decision making as an organizational and research activity. The Editors are two of the leading international experts in decision making and contribute to the Handbook with five original Chapters that offer an appraisal of the field and suggestions for research, as well as the current status of decision making practice and suggestion for improvement.
Eating and its Disorders features contributions by international experts in the field of eating disorders which represent an overview of the most current knowledge relating to the assessment, treatment, and future research directions of the study of eating-related disorders. Presents the newest models and theories for use in the treatment of patients with eating disorders Written specifically to fulfill the needs of clinical psychologists and therapists Includes coverage of important service related issues for working with people with eating disorders Features chapters from a global group of authors which highlight differing methods and perspectives that can be incorporated into clinical practice
This groundbreaking two-volume handbook provides a comprehensive collection of evidence-based analyses of the causes, treatment, and prevention of eating disorders. A two-volume handbook featuring contributions from an international group of experts, and edited by two of the leading authorities on eating disorders and body image research Presents comprehensive coverage of eating disorders, including their history, etiological factors, diagnosis, assessment, prevention, and treatment Tackles controversies and previously unanswered questions in the field Includes coverage of DSM-5 and suggestions for further research at the end of each chapter 2 Volumes
Sarcopenia is a major therapeutic challenge and a public health priority in both the US and Europe. More than two decades after the word was first used to define a distinct clinical condition, the definition of sarcopenia remains open for discussion,nd its clinical relevance is still not fully understood. This book provides some answers. It is a valuable addition to the existing literature, providing a one-stop shop for state-of-the-art information on a topic of particular relevance for geriatricians and all those who care for the older population. Sarcopenia has serious health consequences of sarcopenia in terms of frailty, disability, morbidity, and mortality. Identifying high risk groups of older people is straightforward, but making a diagnosis is more difficult. Having addressed the definition of sarcopenia the book therefore goes on to discuss current open questions that concern the clinical management of the condition. Chapters cover nosology, pathophysiology, clinical identification, and treatment: for example, is sarcopenia a normal part of the ageing process? When does it become a disease state? Is it only a morphologic or functional abnormality, or is it an age-related disease? Epidemiological, clinical, diagnostic and therapeutic aspects of sarcopenia are covered, as well as possible methods of prevention and treatment options. Defines and explains the clinical relevance of sarcopenia Covers all recent scientific evidence Discusses treatment options Considers ways of prevention Written by experts in the field from both the US and Europe, this book will be of practical interest to geriatricians, clinicians and professionals working in nursing homes, nutrition and sport medicine. It is also a valuable and comprehensive reference work for professionals, post-graduates and researchers on age-related diseases, disability, nutrition and geriatric medicine.
Featuring leading international authors working in clinical psychology and psychiatry, this handbook offer the most in-depth coverage of social anxiety disorder, including personality factors in SAD, and multicultural issues in the diagnosis, case conceptualization, and treatment of SAD. A multi-contributed, internationally diverse handbook covering all major elements of social anxiety disorder, offering an invaluable teaching tool This unique text contributes significantly to the field by summarizing the current state of research in the area and outlining future directions Provides a comprehensive overview of applied, empirically-supported techniques in the conceptualization, assessment, and treatment of SAD
Every medical student must be able to take an accurate history and perform a physical examination. This third edition of History and Clinical Examination at a Glance provides a concise, highly illustrated companion to help you develop these vital skills as you practice on the wards. Building on an overview of the patient/doctor relationship and basic enquiry, the text supports learning either by system or presentation of common conditions, with step-by-step and evidence-based information to support clinical examination and help you formulate a sound differential diagnosis. History and Clinical Examination at a Glance features: Succinct text and full colour illustrations, including many brand new clinical photographs A new section on the development of communication skills, which explains how to communicate in different circumstances, and with different groups of people A self-assessment framework which can be used individually, by tutors, or in group practice to prepare for OSCEs History and Clinical Examination at a Glance is the perfect guide for medical, health science students, and junior doctors, as an ideal resource for clinical attachments, last-minute revision, or whenever you need a refresher.