A thoroughly updated new edition of the essential reference on the design, practice, and analysis of clinical trials Clinical Trials Dictionary: Terminology and Usage Recommendations, Second Edition presents clear, precise, meticulously detailed entries on all aspects of modern-day clinical trials. Written and compiled by one of the world’s leading clinical trialists, this comprehensive volume incorporates areas of medicine, statistics, epidemiology, computer science, and bioethics—providing a treasure trove of key terms and ideas. This new edition continues to supply readers with the A–Z terminology needed to design, conduct, and analyze trials, introducing a vocabulary for the characterization and description of related features and activities. More than 300 new entries are now included, reflecting the current usage practices and conventions in the field, along with usage notes with recommendations on when to use the term in question. Detailed biographical notes highlight prominent historical figures and institutions in the field, and an extensive bibliography has been updated to provide readers with additional resources for further study. The most up-to-date work of its kind, Clinical Trials Dictionary, Second Edition is an essential reference for anyone who needs to report on, index, analyze, or assess the scientific strength and validity of clinical trials.
Following the success of the first collection of Stahl's Case Studies, published in 2011, we are pleased to present this completely new selection of clinical stories. Designed with the distinctive user-friendly presentation readers have become accustomed to and making use of icons, questions/answers and tips, these cases address complex issues in an understandable way and with direct relevance to the everyday experience of clinicians. Covering a wide-ranging and representative selection of clinical scenarios, each case is followed through the complete clinical encounter, from start to resolution, acknowledging all the complications, issues, decisions, twists and turns along the way. The book is about living through the treatments that work, the treatments that fail, and the mistakes made along the journey. This is psychiatry in real life - these are the patients from your waiting room - this book will reassure, inform and guide better clinical decision making. Optional posttests with CME credit are available for a fee (waived for NEI members). For more information, contact the Neuroscience Education Institute.
This book is the first to bring together new research to offer a hands-on clinical guide to treating people with all types of obsessive compulsive disorder (OCD) using an inference-based therapy (IBT). Provides clinical examples from the full range of OCD subtypes Coverage integrates theory and application Decribes case management in detail – from initial assessment to terminating therapy and follow-up Shows how IBT can also be generalized and applied to other serious psychiatric disorders
The monograph shows the opportunity to study the pathogenesis of mental disorders in epilepsy based on the characteristics of its fl ow using clinical methods, structural dynamic, epidemiological and statistical analysis. Structural and dynamic analysis of the major clinical manifestations of the disease (features of personality changes, paroxysmal disorders, psychotic symptoms, dementia) held in accordance with the main patterns of development of the disease, its types and stages. On the basis of the multi-axial classifi cation of epilepsy was developed a model that allows in a retrospective analysis of an-amnestic data and clinical assessment to establish clinical and social criteria for prognosis prediction.
Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.
Written by one of the great teachers of Anatomy, this 50th anniversary edition of Clinical Anatomy continues to provide thousands of medical students, postgraduate trainees and junior doctors across the world with essential anatomical information within a clinical setting. It is particularly appropriate for those preparing for the Membership of the Royal College of Surgeon's Exam. For this new edition, Professor Harold Ellis is joined, for the first time, by a co-author. Professor Vishy Mahadevan is Barber's Company Reader in Anatomy at the Royal College of Surgeons, a renowned teacher of surgical trainees and is also an examiner for the MRCS Exam. Together they provide a detailed, easy-to-follow structured text suitable for anatomy students and trainees of all levels. Fully revised and updated, this new edition features new and re-drawn illustrations, new images of normal anatomy (radiographs, CTs and NMRs) to aid understanding, a revised neuroanatomy section to provide greater clarity and an expansion of the lower limb section. In order to provide revision support, Clinical Anatomy has its own website featuring digital flashcards of all the images found in the textbook available to download for free at www.ellisclinicalanatomy.co.uk
How adequate are our theories of globalisation for analysing the worlds we share with others? In this provocative new book, Henrietta Moore asks us to step back and re-examine in a fresh way the interconnections normally labeled 'globalisation'. Rather than beginning with abstract processes and flows, Moore starts by analyzing the hopes, desires and satisfactions of individuals in their day-to-day lives. Drawing on a wide range of examples, from African initiation rituals to Japanese anime, from sex in virtual worlds to Schubert songs, Moore develops a theory of the ethical imagination, exploring how ideas about the human subject, and its capacities for self-making and social transformation, form a basis for reconceptualizing the role and significance of culture in a global age. She shows how the ideas of social analysts and ordinary people intertwine and diverge, and argues for an ethics of engagement based on an understanding of the human need to engage with cultural problems and seek social change. This innovative and challenging book is essential reading for anyone interested in the key debates about culture and globalization in the contemporary world.
Muscle weakness with ageing is almost inevitable, generally beginning to manifest beyond the age of 40, and is usually unstoppable. It can lead to reduced mobility, increased risk of falling, injury, and even death. But “you’re just getting old” is not a sufficient diagnosis. Specific causes of neuromuscular symptoms may explain progressive muscle weakness, and should be investigated for potential treatment. Muscle Ageing, Inclusion-Body Myositis and Myopathies explores the clinical and pathological expression of muscle weakness in aging persons. Case studies demonstrate how physicians can more accurately diagnose weakening elderly patients and make better management decisions. It also explores sporadic inclusion-body myositis and hereditary inclusion-body myopathies. The former, the most common progressive muscle disease in the over 50s, is frequently under-diagnosed and, with the increasing population of aged individuals, is presenting a greater challenge. This disease of muscle has pathological similarities with the well-known Alzheimer and Parkinson brain diseases. Edited and written by a leading international cast of authors, Muscle Ageing, Inclusion-Body Myositis and Myopathies provides a state-of-the-art guide to ageing-associated neuromuscular disorders. It should be in the hands of all those involved in the care of aging and muscle-weakened patients. Titles of Related Interest Neuromuscular Disorders Tawil and Vennance (eds); ISBN 978-0-470-65456-9 European Handbook of Neurological Management, Vol 1, 2e Gilhus, Barnes, Brainin (eds); ISBN 978-1-4051-8533-2 European Handbook of Neurological Management, Vol 2, 2e Gilhus, Barnes, Brainin (eds); ISBN 978-1-4051-8534-9
The Handbook of Transformative Learning The leading resource for the field, this handbook provides a comprehensive and critical review of more than three decades of theory development, research, and practice in transformative learning. The starting place for understanding and fostering transformative learning, as well as diving deeper, the volume distinguishes transformative learning from other forms of learning, explores future perspectives, and is designed for scholars, students, and practitioners. Praise for The Handbook of Transformative Learning «This book will be of inestimable value to students and scholars of learning irrespective of whether or not their emphasis is on transformative learning. It should find its way to the reference bookshelves of every academic library focusing on education, teaching, learning, or the care professions.» —Peter Jarvis, professor of continuing education, University of Surrey «Can there be a coherent theory of transformative learning? Perhaps. This handbook goes a long way to answering this question by offering a kaleidoscope of perspectives, including non-Western, that consider the meaning and practice of transformativelearning.» —Shauna Butterwick, associate professor, University of British Columbia «This handbook will be valuable and accessible to both scholars and practitioners who are new to the study of adult education and transformative learning and to more seasoned scholars who seek a sophisticated analysis of the state of transformative learning thirty years after Mezirow first shared his version of a then-fledgling theory of adult learning.» —Jovita Ross-Gordon, professor and program coordinator, MA in Adult Education, Texas State University
This unique book provides up-to-date information on the appropriateness of both medical and surgical treatment options for a broad spectrum of urological conditions based on the current best evidence. Written by an international team of authors that stand out through their specialty expertise and leadership in practicing evidence-based urology, this book provides practical recommendations for the care of individual patients. Each chapter addresses a series of focused clinical questions that are addressed in a systematic fashion, including a comprehensive literature search, a rating of the quality of evidence, and an assessment of ratio of benefit and harm of a given treatment option. Evidence-Based Urology is an invaluable source of evidence-based information distilled into guidance for clinical practice.
The legal implications of conducting clinical research and trials are becoming more complex. Everyone involved in clinical research increasingly needs to be aware of not only the ethical issues at stake but also how the law affects medical practice and research. Much of clinical research and trial law and litigation is comparatively recent and researchers need to ensure current compliance on a wide range of issues. Including: standards and duty of care informed consent conflicts of interest research contracts establishing clinical trials the disclosure and withholding of clinical trial results Clinical Research and the Law comprehensively discusses these topics and provides the answers to the legal questions and potential pitfalls encountered in medical research. It is an up-to-date, practical guide for clinical investigators and their institutional administrators, particularly risk managers and research administrators, as well as healthcare administrators and members of institutional review boards. This book is also a key resource for medical students, postgraduate research students, practicing attorneys and counselors for teaching hospitals and institutions undertaking clinical research and contract research organizations.
As a foundation to a successful career in clinical medicine every physician needs to be able to establish a good rapport with the patient, accurately record all presenting symptoms and signs, and finally make an accurate diagnosis. "Internal diseases propedeutics" offers a thorough grounding in the principles of the physical examination and provides a detailed account of the symptoms and signs of diseases affecting the body systems. This textbook includes chapters on diagnosis of pulmonary, cardiovascular, digestive, genitourinary, nutritional, endocrine disorders and diseases of blood. The book covers both basic clinical skills, and high technology investigations and interventions that are utilised today by the physician. The "Internal diseases propedeutics" ensures that it will remain an invaluable source of information for all medical students and junior doctors of all specialities in their early years of clinical practice.
A guide for getting your perfectionism to work for you Is perfectionism a good thing or does it get in our way? In The Perfectionist's Handbook, clinical psychologist Jeff Szymanski helps readers navigate their way out of the «perfectionism paradox»: if your intentions are good (wanting to excel) and the outcomes you want are reasonable (to feel competent and satisfied), why would perfectionism backfire and result in unhappiness and stress? Learn when perfectionism will pay off, and when and why it sabotages you. Specific strategies are outlined throughout the book to help readers transform their perfectionism from a liability to an asset. There is no reason to eliminate perfectionism altogether—instead, build on what's working and change what's not. The Perfectionist's Handbook helps readers to: Distinguish between intention and strategy as a way of improving outcomes Identify diminishing returns and how to redistribute time and resources Make the most of mistakes rather than being preoccupied with trying to avoid them Learn to focus on your «Top 10» list as a way of getting the most out of your life Access others more effectively as a way of improving performance Obtain more balance in their lives
With the desire for dental implant therapy ever escalating, clinicians are faced with the challenge of augmenting deficient natural physiology to provide effective sites for implantation. Implant Site Development helps the clinician decide if, when, and how to create a ridge site amenable to implantation. This practical book offers solutions to many implant site preservation scenarios, discussing different treatment options, timing, a variety of materials and techniques, and their application to the clinical practice. With a unique integrated clinical approach, Implant Site Development covers a range of site development techniques. Highly illustrated, Implant Site Development presents diagrams and clinical photographs to aid with clinical judgment and will prove useful for any dental professional involved in implant therapy, from general practitioners to prosthodontists, but especially surgeons. This literature-based, yet user-friendly, reference will be indispensable to the novice or veteran clinician.
A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.
This book provides a practical guide to analysis of simple and complex method comparison data, using Stata, SAS and R. It takes the classical Limits of Agreement as a starting point, and presents it in a proper statistical framework. The model serves as a reference for reporting sources of variation and for providing conversion equations and plots between methods for practical use, including prediction uncertainty. Presents a modeling framework for analysis of data and reporting of results from comparing measurements from different clinical centers and/or different methods. Provides the practical tools for analyzing method comparison studies along with guidance on what to report and how to plan comparison studies and advice on appropriate software. Illustrated throughout with computer examples in R. Supported by a supplementary website hosting an R-package that performs the major part of the analyses needed in the area. Examples in SAS and Stata for the most common situations are also provided. Written by an acknowledged expert on the subject, with a long standing experience as a biostatistician in a clinical environment and a track record of delivering training on the subject. Biostatisticians, clinicians, medical researchers and practitioners involved in research and analysis of measurement methods and laboratory investigations will benefit from this book. Students of statistics, biostatistics, and the chemical sciences will also find this book useful.